Synthesis, anti-arthritic and antioxidant activities of novel 1,3,4-oxadizole derivatives
By: Banylla Felicity Dkhar Gatphoh
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Contributor(s): Revanasiddappa, B. C | Vijay Kumar, M.
Publisher: Mumbai Indian Drug Manufacture's Association - IDMA 2018Edition: Vol. 55(12), December.Description: 18-23.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian drugsSummary: A series of novel 2,5-disubstituted-1,3,4-oxadiazoles (2a-j) were synthesized by the reaction of 4-hydroxy benzhydrazide (1) and aromatic aldehydes (2) in the presence of small amounts of ferric chloride in methanol as solvent medium. The synthesized compounds were characterized by various spectrochemical methods including 1H-NMR, IR and MS spectroscopy. The newly synthesized compounds were evaluated for In vitro antioxidant and anti-arthritic activities. Some of the synthesized compounds showed moderate antioxidant and antiarthritic activities.
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2018378 |
A series of novel 2,5-disubstituted-1,3,4-oxadiazoles (2a-j) were synthesized by the reaction of 4-hydroxy benzhydrazide (1) and aromatic aldehydes (2) in the presence of small amounts of ferric chloride in methanol as solvent medium. The synthesized compounds were characterized by various spectrochemical methods including 1H-NMR, IR and MS spectroscopy. The newly synthesized compounds were evaluated for In vitro antioxidant and anti-arthritic activities. Some of the synthesized compounds showed moderate antioxidant and antiarthritic activities.
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